Immune Modulation by Parenteral Lipid Emulsions

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dc.contributor.authorGeert J.A. Wanten
dc.contributor.authorPhilip C. Calder
dc.date.accessioned2014-05-03T10:28:10Z
dc.date.available2014-05-03T10:28:10Z
dc.date.issued2007-05
dc.description.abstractTotal parenteral nutrition is the final option for nutritional support of patients with severe intestinal failure. Lipid emulsions constitute the main source of fuel calories and fatty acids (FAs) in parenteral nutrition formulations. However, adverse effects on patient outcomes have been attributed to the use of lipids, mostly in relation to impaired immune defenses and altered inflammatory responses. Over the years, this issue has remained in the limelight, also because technical advances have provided no safeguard against the most daunting problems, ie, infectious complications. Nevertheless, numerous investigations have failed to produce a clear picture of the immunologic characteristics of the most commonly used soybean oil–derived lipid emulsions, although their high content of n–6 polyunsaturated FAs (PUFAs) has been considered a drawback because of their proinflammatory potential. This concern initiated the development of emulsions in which part of the n–6 FA component is replaced by less bioactive FAs, such as coconut oil (rich in medium-chain saturated FAs) or olive oil (rich in the n–9 monounsaturated FA oleic acid). Another approach has been to use fish oil (rich in n–3 PUFA), the FAs of which have biological activities different from those of n–6 PUFAs. Recent studies on the modulation of host defenses and inflammation by fish-oil emulsions have yielded consistent data, which indicate that these emulsions may provide a tool to beneficially alter the course of immune-mediated conditions. Although most of these lipids have not yet become available on the US market, this review synthesizes available information on immunologic characteristics of the different lipids that currently can be applied via parenteral nutrition support.en_US
dc.identifier.citationAmerican Journal of Clinical Nutrition Vol.: 85, No.: 5, May, 1 2007 [Page 1171-1184]en_US
dc.identifier.urihttp://hdl.handle.net/123456789/927
dc.language.isoenen_US
dc.publisherAmerican Society for Clinical Nutritionen_US
dc.subjectTotal parenteral nutritionen_US
dc.subjectlipid emulsionen_US
dc.subjectimmunologyen_US
dc.subjectinflammationen_US
dc.subjectfatty acidsen_US
dc.subjecteicosanoidsen_US
dc.titleImmune Modulation by Parenteral Lipid Emulsionsen_US
dc.typeArticleen_US

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