A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats
| dc.contributor.author | Ana Belen Granado Serrano | |
| dc.contributor.author | Maria Angeles Martin | |
| dc.contributor.author | Laura Bravo Luis Goya | |
| dc.contributor.author | Sonia Ramos | |
| dc.date.accessioned | 2014-04-05T11:10:09Z | |
| dc.date.available | 2014-04-05T11:10:09Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The effects of cocoa feeding against N-nitrosodiethylamine (DEN)-induced liver injury were studied in rats. Animals were divided into five groups. Groups 1 and 2 were fed with standard and cocoa-diet, respectively. Groups 3 and 4 were injected with DEN at 2 and 4 weeks, and fed with standard and cocoa-diet, respectively. Group 5 was treated with DEN, received the standard diet for 4 weeks and then it was replaced by the cocoa-diet. DEN-induced hepatic damage caused a significant increase in damage markers, as well as a decrease in the hepatic glutathione, diminished levels of p-ERK and enhanced protein carbonyl content, caspase-3 activity and values of p-AKT and p-JNK. The cocoa-rich diet prevented the reduction of hepatic glutathione concentration and catalase and GPx activities in DEN-injected rats, as well as diminished protein carbonyl content, caspase-3 activity, p-AKT and p-JNK levels, and increased GST activity. However, cocoa administration did not abrogate the DEN-induced body weight loss and the increased levels of hepatic-specific enzymes and LDH. These results suggested that cocoa-rich diet attenuates the DEN-induced liver injury | en_US |
| dc.identifier.citation | Food and Chemical Toxicology 47 (2009) 2499–2506 | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/276 | |
| dc.language.iso | en | en_US |
| dc.subject | Cocoa | en_US |
| dc.subject | Liver | en_US |
| dc.subject | Antioxidant defences | en_US |
| dc.subject | Cell death | en_US |
| dc.subject | Survival/proliferation pathways | en_US |
| dc.title | A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats | en_US |
| dc.type | Article | en_US |