Cocoa Butter and Safflower Oil Elicit Different Effects on Hepatic Gene Expression and Lipid Metabolism in Rats

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dc.contributor.authorCarolina Gustavsson
dc.contributor.authorPaolo Parini
dc.contributor.authorJovanca Ostojic
dc.contributor.authorLouisa Cheung
dc.contributor.authorJin Hu
dc.contributor.authorGunnar Norstedt
dc.contributor.authorKerstin Brismar
dc.contributor.authorFaheem Tahir
dc.contributor.authorFahad Zadjali
dc.date.accessioned2014-04-05T06:26:04Z
dc.date.available2014-04-05T06:26:04Z
dc.date.issued2009
dc.description.abstractThe aim of this study was to compare the effects of cocoa butter and safflower oil on hepatic transcript profiles, lipid metabolism and insulin sensitivity in healthy rats. Cocoa butter-based high-fat feeding for 3 days did not affect plasma total triglyceride (TG) levels or TG-rich VLDL particles or hepatic insulin sensitivity, but changes in hepatic gene expression were induced that might lead to increased lipid synthesis, lipotoxicity, inflammation and insulin resistance if maintained. Safflower oil increased hepatic b-oxidation, was beneficial in terms of circulating TG-rich VLDL particles, but led to reduced hepatic insulin sensitivity. The effects of safflower oil on hepatic gene expression were partly overlapping with those exerted by cocoa butter, but fewer transcripts from anabolic pathways were altered. Increased hepatic cholesterol levels and increased expression of hepatic CYP7A1 and ABCG5 mRNA, important gene products in bile acid production and cholesterol excretion, were specific effects elicited by safflower oil only. Common effects on gene expression included increased levels of p8, DIG-1 IGFBP-1 and FGF21, and reduced levels of SCD-1 and SCD-2. This indicates that a lipid-induced program for hepatic lipid disposal and cell survival was induced by 3 days of high-fat feeding, independent on the lipid source. Based on the results, we speculate that hepatic TG infiltration leads to reduced expression of SCD-1, which might mediate either neutral, beneficial or unfavorable effects on hepatic metabolism upon high-fat feeding, depending on which fatty acids were provided by the dieten_US
dc.identifier.citationLipids (2009) 44:1011–1027en_US
dc.identifier.urihttp://hdl.handle.net/123456789/251
dc.language.isoenen_US
dc.subjectDietary faten_US
dc.subjectHepatic lipid metabolismen_US
dc.subjectGene expressionen_US
dc.titleCocoa Butter and Safflower Oil Elicit Different Effects on Hepatic Gene Expression and Lipid Metabolism in Ratsen_US
dc.typeArticleen_US

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