Effect of Fatty Acids Isolated from Edible Oils Like Mustard, Linseed or Coconut on Astrocytes Maturation

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dc.contributor.authorAnindita Joardar
dc.contributor.authorSumantra Das
dc.date.accessioned2014-04-26T10:38:51Z
dc.date.available2014-04-26T10:38:51Z
dc.date.issued2007
dc.description.abstractThe omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA, 22:6n-3) has been previously shown to facilitate some of the vital functions of astrocytes. Since some dietary oils contain a-linolenic acid (ALA, 18:3n-3), which is a precursor of DHA, we examined their effect on astrocyte development. Fatty acids (FAs) were isolated from commonly used oils and their compositions were determined by GLC. FAs from three oils, viz. coconut, mustard and linseed were studied for their effect on astrocyte morphology. Parallel studies were conducted with FAs from the same oils after heating for 72 h. Unlike coconut oil, FAs from mustard and linseed, both heated and raw, caused significant morphogenesis of astrocytes in culture. ß-AR binding was also substantially increased in astrocytes treated with FAs from raw mustard and linseed oils as compared to astrocytes grown in normal medium. The expression profile of the isoforms of GFAP showed that astrocyte maturation by FAs of mustard and linseed oil was associated with appearance of acidic variants of GFAP and disappearance of some neutral isoforms similar to that observed in cultures grown in serum containing medium or in the presence of DHA. Taken together, the study highlights the contribution of specific dietary oils in facilitating astrocyte development that can have potential impact on human health.en_US
dc.identifier.citationCell Mol Neurobiol (2007) 27:973–983 DOI 10.1007/s10571-007-9204-7en_US
dc.identifier.urihttp://hdl.handle.net/123456789/652
dc.language.isoenen_US
dc.publisherCell Mol Neurobiolen_US
dc.subjectGliaen_US
dc.subjectAstrocytesen_US
dc.subjectb-Adrnergic receptorsen_US
dc.subjectGlial fibrillary acidic proteinen_US
dc.subject2D electrophoresisen_US
dc.titleEffect of Fatty Acids Isolated from Edible Oils Like Mustard, Linseed or Coconut on Astrocytes Maturationen_US
dc.typeArticleen_US

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