Protective Effect of Areca Catechu Extract on Ethanol Induced Gastric Mucosal Lesions in Rats
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Date
2008
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Abstract
In the present study, the antiulcerogenic activity of defatted ethanol extract of Areca catechu was investigated. Ethanol treatment significantly increased the levels of gastric mucosal malondialdehyde (MDA, an index of lipid peroxidation), nitric oxide (NO) and increase in the activities of myeloperoxidase (MPx, an index neutrophil infiltration) and xanthine oxidase (XO) enzymes. Pretreatment with A. catechu in the doses of 250mg/kg and 500mg/kg body weight, prevented the formation of gastric mucosal MDA, NO contents and activities of MPx and XO. Ethanol induction also showed a significant reduction of the gastric mucosal glutathione (GSH), sialic acid and deoxyribo nucleic acid (DNA) levels. The pretreatment with A. catechu maintained the levels similar to normal control level. Based on these data, the protective effects of both 250mg/kg and 500mg/kg doses of A. catechu on ethanol induced gastric mucosal injury may be attributed to its antioxidant effect.
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Keywords
Antiulcer, Areca catechu, Polyphenol, Antioxidants
Citation
Pharmacologyonline 1: 97-106 (2008)