Hypercholesterolemia Abrogates an Increased Resistance of Diabetic Rat Hearts to ischemia-reperfusion Injury

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dc.contributor.authorAdameova, A.
dc.contributor.authorKuzelova, M.
dc.contributor.authorAndelova, E.
dc.contributor.authorFaberova, V.
dc.contributor.authorPancza, D.
dc.contributor.authorSvec, P.
dc.contributor.authorZiegelhoffer, A.
dc.contributor.authorRavingerova, T.
dc.date.accessioned2014-05-03T09:30:32Z
dc.date.available2014-05-03T09:30:32Z
dc.date.issued2007
dc.description.abstractBoth, Diabetes Mellitus (dm) and Hypercholesterolemia (hch) are Known as Risk Factors of Ischemic Heart Disease, However, the Effects of Experimental Dm, as well as of Hch Alone, on ischemia/reperfusion-induced Myocardial Injury are not Unequivocal.We have Previously Demonstrated an Enhanced Resistance to ischemia-induced Arrhythmias in Rat Hearts in the Acute Phase of Dm.Our Objectives were thus to Extend our Knowledge on how Dm in Combination with Hch, a Model that is Relevant to Diabetic Patients with Altered Lipid Metabolism, may Affect the Size of Myocardial Infarction and Susceptibility to Arrhythmias.A Combination of Streptozotocin (stz;80 Mg/kg, I.P.) and the fat-cholesterol Diet (1% Cholesterol, 1% Coconut Oil;Fchd) was Used as a double-disease Model Mimicking Dm and Hch Simultaneosly Occurring in Humans.Following 5 Days after Stz Injection and Fchd Leading to Increased Blood Glucose and Cholesterol Levels, Anesthetized open-chest Diabetic, diabetic-hypercholesterolemic (DM-HCH) and age-matched Control Rats were Subjected to 6-min Ischemia (occlusion of Lad Coronary Artery) Followed by 10 Reperfusion to Test Susceptibility to Ventricular Arrhythmias in the in Vivo Experiments and to 30-min Ischemia and Subsequent 2-h Reperfusion for the Evaluation of the Infarct Size (is) in the Langendorff-perfused Hearts.The Incidence of the most life-threatening Ventricular Arrhythmia, Ventricular Fibrillation, was Significantly Increased in the DM-HCH Rats as Compared with non-diabetic Control Animals (100% Vs.50%;p<0.05).Likewise, Arrhythmia Severity Score (as) was Significantly Higher in the DM-HCH Rats than in the Controls (4.9±0.2 Vs. 3.5±0.5;p<0.05), but was not Increased in the Diabetic Animals (as 3.7±0.9;p>0.05 Vs.Controls).Diabetic Hearts Exhibited a Reduced is (15.1±3.0% of the Area at Risk Vs.37.6±2.8% in the Control Hearts; p<0. 05), However, a Combination of Dm and Hch Increased the Size of Myocardial Infarction to that Observed in the Controls. In Conclusion, Hch Abrogates Enhanced Resistance to ischemia-reperfusion Injury in the Diabetic Rat Heart.en_US
dc.identifier.citationMolecular and Cellular Biochemistry Vol.: 295, No.: 1-2, January 2007 [Page 129-136]en_US
dc.identifier.urihttp://hdl.handle.net/123456789/919
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.subjectarrhythmiasen_US
dc.subjectexperimental diabetesen_US
dc.subjecthypercholesterolemiaen_US
dc.subjectinfarctionen_US
dc.subjectmyocardial ischemia-reperfusion injuryen_US
dc.titleHypercholesterolemia Abrogates an Increased Resistance of Diabetic Rat Hearts to ischemia-reperfusion Injuryen_US
dc.typeArticleen_US

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