Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue

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dc.contributor.authorAllain Amador Bueno
dc.contributor.authorLila Missae Oyama
dc.contributor.authorCristiane de Oliveira
dc.contributor.authorLuciana Pelegrini Pisani
dc.contributor.authorEliane Beraldi Ribeiro
dc.contributor.authorVera Lucia Flor Silveira
dc.contributor.authorClaudia Maria Oller do Nascimento
dc.date.accessioned2014-04-29T05:36:12Z
dc.date.available2014-04-29T05:36:12Z
dc.date.issued2008
dc.description.abstractObesity is positively correlated to dietary lipid intake, and the type of lipid may play a causal role in the development of obesity-related pathologies. A major protein secreted by adipose tissue is adiponectin, which has antiatherogenic and antidiabetic properties. The aim of this study was to evaluate the effects of four different highfat diets (enriched with soybean oil, fish oil, coconut oil, or lard) on adiponectin gene expression and secretion by the white adipose tissue (WAT) of mice fed on a selected diet for either 2 (acute treatment) or 60 days (chronic treatment). Additionally, 3T3-L1 adipocytes were treated for 48 h with six different fatty acids: palmitic, linoleic, eicosapentaenoic (EPA), docosahexaenoic (DHA), lauric, or oleic acid. Serum adiponectin concentration was reduced in the soybean-, coconut-, and lard-enriched diets in both groups. Adiponectin gene expression was lower in retroperitoneal WAT after acute treatment with all diets. The same reduction in levels of adiponectin gene expression was observed in epididymal adipose tissue of animals chronically fed soybean and coconut diets and in 3T3-L1 cells treated with palmitic, linoleic, EPA, and DHA acids. These results indicate that the intake of certain fatty acids may affect serum adiponectin levels in mice and adiponectin gene expression in mouse WAT and 3T3-L1 adipocytes. The effects appear to be time dependent and depot specific. It is postulated that the downregulation of adiponectin expression by dietary enrichment with soybean oil or coconut oil may contribute to the development of insulin resistance and atherosclerosisen_US
dc.identifier.citationPflugers Arch - Eur J Physiol (2008) 455:701–709en_US
dc.identifier.urihttp://hdl.handle.net/123456789/677
dc.language.isoenen_US
dc.subjectWhite adipose tissuesen_US
dc.subjectAdiponectinen_US
dc.subjectHigh-fat dietsen_US
dc.subjectMiceen_US
dc.subject3T3-L1en_US
dc.titleEffects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissueen_US
dc.typeArticleen_US

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