Mohammadreza KhanmohammadiMohammadjavad Hosseinnia KojidiAmir Bagheri GarmarudiAhmad AshurMajid Soleymani2014-05-162014-05-162009J Surfact Deterg (2009) 12:37–41http://hdl.handle.net/123456789/1340An analytical procedure was developed to monitor the batch reaction of coconut oil and diethanolaminewhich also would determine the cocodiethanolamide (CDEA) content of the final product. The method was based on attenuated total reflectance Fourier transform infrared spectrometry utilizing partial least squares regression. The calibration was modeled in the 1,781–1,714 and 1,658–1,639 cm-1 spectral regions for coconut oil and CDEA respectively. The models were then applied to predict the amidation process yield and to monitor the in situ kinetics of reactions between coconut oil andDEA.The rootmean square error of prediction was 0.590 and 0.336 for coconut oil and CDEA respectively. The proposed method can also be successfully applied to the determination of purity in commercial grade CDEA samples and would give reliable results in comparison with the potentiometric titration reference method.enamidationcocodiethanolamidATR-FTIR spectrometrypartial least squaresquantitativemonitoringArticle